48v motor installed in a 16" wheel is not a problem,also the thumb throttles. see here
http://fusinmotors.com/plugins/content/multithumb/thumbs/b.160.120.16777215.0..stories.ebikekitsf.thumbthrottle.jpg.
If you wish to use 2 motors on each of the trailer rear wheels, you might have to consider the differentials problem, otherwise there might be difficulty in direction turning, anyway we are not very professional in this.
In China people use differential motor for heavy load tricycles, see the attached photo, power could be 48v/350w or 48v/500w, max torque 80NM, output rpm 260, this should be the best choice for trailer applications.
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